What should I know before I use KEYTRUDA?
What if I am taking other medicines?
How do I use KEYTRUDA?
What should I know while using KEYTRUDA?
Are there any side effects?
Why am I using KEYTRUDA?
What should I know before I use KEYTRUDA?
What if I am taking other medicines?
How do I use KEYTRUDA?
What should I know while using KEYTRUDA?
Are there any side effects?
Product details
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Things you should do
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Remind any doctor, dentist or pharmacist you visit that you are using KEYTRUDA.
If you miss a dose of KEYTRUDA, call your doctor right away to reschedule your appointment
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Driving or using machines
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Be careful before you drive or use any machines or tools until you know how KEYTRUDA affects you.
Fatigue has been reported following administration of KEYTRUDA.
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What should I know before I use KEYTRUDA?
What if I am taking other medicines?
How do I use KEYTRUDA?
What should I know while using KEYTRUDA?
Are there any side effects?
Why am I using KEYTRUDA?
What should I know before I use KEYTRUDA?
What if I am taking other medicines?
How do I use KEYTRUDA?
What should I know while using KEYTRUDA?
Are there any side effects?
Product details
Download PDF Standard Print
Download PDF Large Print
-
Audio under revision, check back soon
Check with your doctor if you:
Pregnancy and breastfeeding
When to take KEYTRUDA
If you miss a dose
Things you should do
Driving or using machines
Looking after your medicine
Serious side effects
Serious side effects
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What to do
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Signs and symptoms of lung problems:
shortness of breath
chest pain
coughing
Signs and symptoms of problems with your intestines:
diarrhoea or more bowel movements than usual
your stools are black, tarry, sticky or have blood or mucus
severe stomach pain or tenderness
Signs and symptoms of liver problems:
nausea or vomiting
feeling less hungry
pain on the right side of your stomach
your skin looks yellow
the whites of your eyes look yellow
dark urine
you bleed or bruise more easily than normal
Signs and symptoms of kidney problems:
changes in the amount or colour of your urine
Signs and symptoms of hormone gland problems (especially the thyroid, pituitary, and adrenal glands):
rapid heartbeat
weight loss
increased sweating
weight gain
hair loss
feeling cold
constipation
your voice gets deeper
muscle aches
dizziness or fainting
headaches that will not go away or unusual headache
Signs and symptoms of blood sugar problems:
feeling more hungry or thirsty
needing to urinate more often
weight loss
Signs and symptoms of skin problems:
rash
itching
skin blistering, peeling or sores
ulcers in mouth or in lining of nose, throat, or genital area
Signs and symptoms of problems in other organs:
muscle pain or weakness
changes in eyesight
stomach area pain with nausea and vomiting (pancreatitis)
confusion, fever, memory problems, or seizures (encephalitis)
swollen lymph nodes, rash or tender lumps on skin, cough, or eye pain (sarcoidosis)
shortness of breath, irregular heartbeat, feeling tired, or chest pain (myocarditis)
inflammation of the heart muscle, which may present as shortness of breath, irregular heartbeat, feeling tired, or chest pain (pericarditis)
inflammation of the covering of the heart and accumulation of fluid around the heart (pericardial effusion)
inflammation of the nerves that may cause pain, weakness, and paralysis in the arms and legs (peripheral neuropathy)
pain, numbness, tingling, or weakness in the arms or legs; bladder or bowel problems including needing to urinate more frequently, urinary incontinence, difficulty urinating and constipation (myelitis)
inflammation of the blood vessels (vasculitis)
decreased function of the parathyroid gland, which may include muscle cramps or spasms, fatigue and weakness (hypoparathyroidism)
pain in the upper right part of the stomach, swelling of the liver or spleen, fatigue, itching or yellowing of the skin or the whites of the eyes (sclerosing cholangitis)
Signs and symptoms of infusion (IV) reactions:
shortness of breath
itching or rash
dizziness
fever
There are possible side effects of treatment with KEYTRUDA in people who have received a transplant:
Rejection of a transplanted organ.
People who have had an organ transplant may have an increased risk of organ transplant rejection. Your doctor should tell you what signs and symptoms you should report and monitor you, depending on the type of organ transplant that you have had.
Complications, including graft-versus-host-disease (GVHD), in people with bone marrow (stem cell) transplant that uses donor stem cells (allogeneic).
These complications can be severe and can lead to death. They may occur if you had this kind of transplant in the past or if you get it in the future. Your doctor will monitor you for the following signs and symptoms: skin rash, liver inflammation, abdominal pain, and diarrhoea.
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Call or see your doctor straight away, or go straight to the Emergency Department at your nearest hospital if you notice any of these serious side effects.
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The following side effects have been reported in clinical trials:
Very common (may affect more than 1 in 10 people)
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What to do
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diarrhoea
nausea
itching
rash
joint pain
back pain
feeling tired
cough
patches of skin which have lost colour
stomach pain
decreased sodium levels in the blood
fever
infections of the upper respiratory tract
low levels of thyroid hormone
a decreased number of white blood cells (which are important in fighting infection) in patients with primary mediastinal B-cell lymphoma
The following side effects have been reported in more than 1 in 5 people when KEYTRUDA was given in combination with chemotherapy:
hair loss
feeling tired
diarrhoea
vomiting
rash
fever
decrease in white blood cell count
decreased appetite
joint pain
swelling of the lining of the digestive system (for example mouth, intestines)
mouth sores
decrease in red blood cell count
nausea
constipation
weight loss
Common side effects when KEYTRUDA is given in combination with lenvatinib include:
low levels of thyroid hormone
high blood pressure
feeling tired
diarrhoea
joint and muscle pain
nausea
decreased appetite
vomiting
mouth sores
weight loss
stomach-area (abdominal) pain
urinary tract infection
protein in your urine
constipation
headache
bleeding
blisters or rash on the palms of your hands and soles of your feet
hoarseness
rash
The most common side effects when KEYTRUDA is given in combination with axitinib are:
diarrhoea
fatigue
high blood pressure
liver problems
low levels of thyroid hormone
decreased appetite
blisters or rash on the palms of your hands and soles of your feet
nausea
mouth sores or swelling of the lining of the mouth, nose, eyes, throat, intestines, or vagina
hoarseness
rash
cough
constipation
The most common side effects when KEYTRUDA is given alone to children are:
fever
vomiting
headache
stomach pain
decrease in number of red blood cells
cough
constipation
Less common side effects can happen.
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Speak to your doctor if you have any of these side effects and they worry you.
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Reporting side effects
What KEYTRUDA contains
Active ingredient
(main ingredient)
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pembrolizumab
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Other ingredients
(inactive ingredients)
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Histidine
Histidine hydrochloride monohydrate
Sucrose
Polysorbate 80
Water for Injections
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What KEYTRUDA looks like
Who distributes KEYTRUDA
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