For more information, see Section 1. Why am I using DBL Fluorouracil Injection BP? in the full CMI.
Talk to your doctor if you have any other medical conditions, have an infection or high temperature, take any other medicines, or if you are pregnant or plan to become pregnant or are breastfeeding.
For more information, see Section 2. What should I know before I use DBL Fluorouracil Injection BP? in the full CMI.
A list of these medicines is in Section 3. What if I am taking other medicines? in the full CMI.
More instructions can be found in Section 4. How do I use DBL Fluorouracil Injection BP? in the full CMI.
Things you should do
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Remind any doctor, dentist or pharmacist you visit that you are using DBL Fluorouracil
Injection BP.
Tell your doctor immediately if you become pregnant; keep all your doctor's appointments
so your progress can be checked.
Take precautions to reduce your risk of infection or bleeding.
Take precautions to protect other people while being treated with this medicine and
for one week after.
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Driving or using machines
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Be careful driving or operating machinery until you know how fluorouracil affects
you.
This medicine may cause tiredness, dizziness or confusion in some people.
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Drinking alcohol
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Alcohol may make any dizziness or confusion worse.
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Looking after your medicine
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This medicine is stored at the hospital.
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Do not use DBL Fluorouracil Injection BP if you:
1. are allergic to fluorouracil, or any of the ingredients listed at the end of this leaflet. Always check the ingredients to make sure you can use this medicine.
2. have an infection or high temperature.
3. have any blood disorder with a reduced number of red blood cells, white blood cells or platelets.
4. have problems with blood clotting.
5. have a lowered immunity due to diseases including HIV / AIDS or cancer.
6. have a lowered immunity due to treatment with medicines such as corticosteroids, cyclosporin or other medicines used to treat cancer (including radiation therapy).
7. have a type of enzyme deficiency called complete dihydropyrimidine dehydrogenase (DPD) deficiency.
Check with your doctor if you:
Pregnancy and breastfeeding
Previous radiation or other cancer treatment
Vaccinations
How much will be given
How long will DBL Fluorouracil Injection BP need to be given
How DBL Fluorouracil Injection BP is given
If too much DBL Fluorouracil Injection BP is given
Things you should do
Call your doctor immediately if you become pregnant while you are being given fluorouracil.
Driving or using machines
Drinking alcohol
Looking after your medicine
Side effects
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What to do
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nausea, vomiting
diarrhoea
loss of appetite
hair loss
skin rash
changes in skin or nail appearance
euphoria
tiredness
headache
dizziness.
fatigue
irritability
restlessness
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Speak to your doctor if you have any of these side effects and they worry you.
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yellowing of the skin or eyes
sore mouth, mouth ulcers
a sore rectum or anus
loss of fingernails or toenails
unsteady walking, muscle weakness or muscle cramps
changes in vision, jerky eye movements, excess tears, or uncomfortable sensitivity
to light
tingling of the hands and/or feet followed by pain, redness and swelling
slurred speech
memory loss, disorientation or confusion
an increased sensitivity of the skin to sunlight (such as redness, itching, swelling,
blistering) which may occur more quickly than normal. Avoid excessive exposure to
the sun and sun lamps, wear sunscreen and protective clothing.
Fever
pain, stiffness or swelling in joints
swelling, redness, or pain near the injection site.
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Speak to your doctor
as soon as possible
if you notice any of these side effects.
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chest pain
irregular and/or rapid heart- beat
loss of consciousness
signs of an infection (e.g. fever, chills, sore throat, cough, pain with urination,
swollen or red skin)
unusual bleeding or bruising (including bloody or black stools, blood in urine)
severe diarrhoea
severe abdominal pain
severe mouth ulceration
difficulty swallowing
seizures, coma
any signs of an allergic reaction such as shortness of breath, wheezing or difficulty
breathing; swelling of the face, lips, tongue or other parts of the body; rash, itching
or hives on the skin.
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Call your doctor immediately or go straight to the Emergency Department at your nearest
hospital if you notice any of these side effects.
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Reporting side effects
What DBL Fluorouracil Injection BP contains
Active ingredient
(main ingredient)
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fluorouracil
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Other ingredients
(inactive ingredients)
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sodium hydroxide; water for injections
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